2-Propylpyrrolidine → N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-propylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2-Propylpyrrolidine	HCID 3795961	—
Reactant	N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-phenylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide	HCID 11215160	—
Reactant	3-({2-[(Tert-butoxycarbonyl)amino]-2-methyl-3-phenylpropoxy}methyl)-5-[(methylsulfonyl)(propyl)amino]benzoic acid	HCID 58856337	—
Product	N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-propylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide	HCID 11272530	—

Reaction Steps

N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-propylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide was prepared from 3-({2-[(tert-butoxycarbonyl)amino]-2-methyl-3-phenylpropoxy}methyl)-5-[(methylsulfonyl)(propyl)amino]benzoic acid (intermediate XI) and 2-propylpyrrolidine following a similar procedure as described for the preparation of N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-phenylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide. HRMS (ES, M+H) calculated for C29H43N3O4S: 530.3047, found: 530.3045.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07354942B2
Source dataset	uspto-grants-2008_04
ORD ID	ord-f0c0244bde4e4bd9be9af999041e420f
Source note	uspto-grants-2008_04