HRID899477

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8902

Dipropylamine

C6H15N

结构：CCCN(c1cc(COCC(C)(N)Cc2ccccc2)cc(C(=O)N2CCCC2c2ccccc2)c1)S(C)(=O)=O

HCID11215160

未命名化合物

结构：CCCN(c1cc(COCC(C)(Cc2ccccc2)NC(=O)OC(C)(C)C)cc(C(=O)O)c1)S(C)(=O)=O

HCID58856337

未命名化合物

2 次

PRODUCTS

生成物

结构：CCCN(CCC)C(=O)c1cc(COCC(C)(N)Cc2ccccc2)cc(N(CCC)S(C)(=O)=O)c1

HCID58856353

未命名化合物

PROCEDURE

实验过程

3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(methylsulfonyl)(propyl)amino]-N,N-dipropylbenzamide was prepared from 3-({2-[(tert-butoxycarbonyl)amino]-2-methyl-3-phenylpropoxy}methyl)-5-[(methylsulfonyl)(propyl)amino]benzoic acid (intermediate XI) and dipropylamine following a similar procedure as described for the preparation of N-{3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-5-[(2-phenylpyrrolidin-1-yl)carbonyl]phenyl}-N-propylmethanesulfonamide. HRMS (ES, M+H) calculated for C28H43N3O4S: 518.3047, found: 518.3051.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b41cfab0301d40848b686879e25307da
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07354942B2
来源说明: uspto-grants-2008_04

反应 SMILES

C(OC(NC(C)(CC1C=CC=CC=1)COCC1C=C(C=C(N(S(C)(=O)=O)CCC)C=1)C(O)=O)=O)(C)(C)C.C(NCCC)CC.[NH2:45][C:46]([CH3:84])([CH2:77][C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1)[CH2:47][O:48][CH2:49][C:50]1[CH:51]=[C:52]([N:69]([CH2:74][CH2:75][CH3:76])[S:70]([CH3:73])(=[O:72])=[O:71])[CH:53]=[C:54]([C:56]([N:58]2[CH2:62][CH2:61][CH2:60][CH:59]2[C:63]2C=CC=C[CH:64]=2)=[O:57])[CH:55]=1>>[NH2:45][C:46]([CH3:84])([CH2:77][C:78]1[CH:79]=[CH:80][CH:81]=[CH:82][CH:83]=1)[CH2:47][O:48][CH2:49][C:50]1[CH:55]=[C:54]([CH:53]=[C:52]([N:69]([S:70]([CH3:73])(=[O:72])=[O:71])[CH2:74][CH2:75][CH3:76])[CH:51]=1)[C:56]([N:58]([CH2:59][CH2:63][CH3:64])[CH2:62][CH2:61][CH3:60])=[O:57]