HRID899481

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5006170

1-(3-chlorophenyl)ethanamine

C8H10ClN

结构：CC(COCc1cc(C(=O)O)cc(C2(C#N)CCCC2)c1)(Cc1ccccc1)NC(=O)OC(C)(C)C

HCID67319183

未命名化合物

PRODUCTS

生成物

结构：CC(NC(=O)c1cc(COCC(C)(N)Cc2ccccc2)cc(C2(C#N)CCCC2)c1)c1cccc(Cl)c1

HCID11353063

未命名化合物

PROCEDURE

实验过程

Prepared from 3-((2-tert-butoxycarbonylamino-2-methyl-3-phenylpropoxy)methyl)-5-(1-cyanocyclopentyl)benzoic acid and 1-(3-chlorophenyl)ethanamine using a similar procedure as described for the preparation of Example 20. HRMS ES calculated for C32H36ClN3O2: 530.2569, found: 530.2565.

WORKUP

后处理

customas described for the preparation of Example 20

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9214270d69c946b79831ea913edcb19a
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07354942B2
来源说明: uspto-grants-2008_04

反应 SMILES

C(OC([NH:8][C:9]([CH3:36])([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:10][O:11][CH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([C:22]2([C:27]#[N:28])[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:21]=1)[C:16]([OH:18])=O)=O)(C)(C)C.[Cl:37][C:38]1[CH:39]=[C:40]([CH:44]([NH2:46])[CH3:45])[CH:41]=[CH:42][CH:43]=1>>[NH2:8][C:9]([CH3:36])([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:10][O:11][CH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([C:22]2([C:27]#[N:28])[CH2:23][CH2:24][CH2:25][CH2:26]2)[CH:21]=1)[C:16]([NH:46][CH:44]([C:40]1[CH:41]=[CH:42][CH:43]=[C:38]([Cl:37])[CH:39]=1)[CH3:45])=[O:18]