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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899483Generated: October 30, 2026

1-(2-Chlorophenyl)ethanamine → 3-((2-Amino-2-methyl-3-phenylpropoxy)methyl)-N-(1-(2-chlorophenyl)ethyl)-5-(1-cyanocyclopentyl)benzamide

https://huagongshe.com/reaction/899483

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chlorophenyl)ethanamineHCID 299767—
Reactant3-((2-Tert-butoxycarbonylamino-2-methyl-3-phenylpropoxy)methyl)-5-(1-cyanocyclopentyl)benzoic acidHCID 67319183—
Product3-((2-Amino-2-methyl-3-phenylpropoxy)methyl)-N-(1-(2-chlorophenyl)ethyl)-5-(1-cyanocyclopentyl)benzamideHCID 11156819—

Reaction Steps

Prepared from 3-((2-tert-butoxycarbonylamino-2-methyl-3-phenylpropoxy)methyl)-5-(1-cyanocyclopentyl)benzoic acid and 1-(2-chlorophenyl)ethanamine using a similar procedure as described for the preparation of Example 20. HRMS ES calculated for C32H36ClN3O2: 530.2569, found: 530.2561.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07354942B2
Source datasetuspto-grants-2008_04
ORD IDord-28e97aeb12d44399aa5fdbbd741ba01a
Source noteuspto-grants-2008_04