HRID899485

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11075603

未命名化合物

结构：C[C@@H](NC(=O)c1cc(CBr)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1

HCID16094314

未命名化合物

结构：CCCCC(N)(COCc1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(N(C)S(C)(=O)=O)c1)Cc1ccccc1

HCID58856333

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](NC(=O)c1cc(COCC(N)(Cc2ccccc2)Cc2ccccc2)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1

HCID11490373

未命名化合物

PROCEDURE

实验过程

Prepared from 3-(N-methyl-N-(methylsulfonyl)amino)-5-(bromomethyl)-N-((R)-1-(4-fluorophenyl)ethyl)benzamide and 2-amino-2-benzyl-3-phenylpropan-1-ol using a similar procedure as described for the preparation of 3-{[(2-amino-2-benzylhexyl)oxy]methyl}-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methyl sulfonyl)amino]benzamide (Example 4). HRMS ES calculated for C34H38FN3O4S: 604.2640, found: 604.2641.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-34033d25338f4e6baa1dce68dc39c03e
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07354942B2
来源说明: uspto-grants-2008_04

反应 SMILES

[CH3:1][N:2]([C:7]1[CH:8]=[C:9]([CH:22]=[C:23]([CH2:25]Br)[CH:24]=1)[C:10]([NH:12][C@@H:13]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH3:14])=[O:11])[S:3]([CH3:6])(=[O:5])=[O:4].[NH2:27][C:28]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:29][OH:30].NC(CC1C=CC=CC=1)(CCCC)COCC1C=C(C=C(N(C)S(C)(=O)=O)C=1)C(N[C@@H](C1C=CC(F)=CC=1)C)=O>>[NH2:27][C:28]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:29][O:30][CH2:25][C:23]1[CH:22]=[C:9]([CH:8]=[C:7]([N:2]([CH3:1])[S:3]([CH3:6])(=[O:5])=[O:4])[CH:24]=1)[C:10]([NH:12][C@@H:13]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH3:14])=[O:11]