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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899525Generated: November 2, 2026

4-(4-Methylphenyl)phenol → 2-(4'-Methyl-biphenyl-4-yloxymethyl)-benzoic acid

https://huagongshe.com/reaction/899525

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Methylphenyl)phenolHCID 1382789—
ReactantMethyl 2-(bromomethyl)benzoateHCID 2734813—
Product2-(4'-Methyl-biphenyl-4-yloxymethyl)-benzoic acidHCID 11174582—

Reaction Steps

2-(4′-Methyl-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 4′-methyl-biphenyl-4-ol (purchased from Maybridge plc, Tintagel, Cornwall, UK or from Intermediate 5) and 2-bromomethyl-benzoic acid methyl ester (Intermediate 1). Yield: 54 mg. Mass spectrum (ES) MH+=319.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07355049B2
Source datasetuspto-grants-2008_04
ORD IDord-2cf0e3560a7748b188582250ad629d39
Source noteuspto-grants-2008_04