4-(4-Methylphenyl)phenol → 2-(4'-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

HRID 899533Notes

Reaction equation

HRID 899533 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C([O:17][C:18]([C:20]1[N:21]=[C:22]([CH2:25]Br)[S:23][CH:24]=1)=[O:19])C>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:25][C:22]3[S:23][CH:24]=[C:20]([C:18]([OH:19])=[O:17])[N:21]=3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 13827894-(4-Methylphenyl)phenol2×HCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate2×

Product 1

HCID 113133602-(4'-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

Procedure

2-(4′-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 4′-methyl-biphenyl-4-ol (purchased from Maybridge plc, Tintagel, Cornwall, UK or from Intermediate 5) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 70 mg. Mass spectrum (ES) MH+=326.

Sources & evidence

ORD record
ord-8d88b2da9b704755af4f7a8e36ea73b4
Source dataset
uspto-grants-2008_04
Patent number
US07355049B2

Reaction notes

Loading…