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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899538Generated: October 26, 2026

4-Hydroxybiphenyl → 4-(Biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acid

https://huagongshe.com/reaction/899538

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxybiphenylHCID 7103—
ReactantEthyl 4-(chloromethyl)-1,3-thiazole-2-carboxylateHCID 10822129—
Product4-(Biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acidHCID 11483748—

Reaction Steps

4-(Biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acid was prepared using general procedure B from 4-phenylphenol (available from Aldrich, Milwaukee, Wis.) and 4-chloromethyl-thiazole-2-carboxylic acid ethyl ester (Intermediate 4). Yield: 54 mg. Mass spectrum (ES) M-OH=294

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07355049B2
Source datasetuspto-grants-2008_04
ORD IDord-0fc94838c7084a47ad6642f928a9795b
Source noteuspto-grants-2008_04