Isopropylamine → HCID 11696440, compound

HRID 899565Notes

Reaction equation

HRID 899565 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[C:16]1[C:17]([CH2:27][CH2:28][CH2:29][C:30]2[CH:35]=CC=CC=2)=C(S([O-])(=O)=O)C=C[C:21]=1[CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:36]([NH2:39])([CH3:38])[CH3:37]>C(#N)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[CH:16]([C:17]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:35]=1)[CH2:21][CH2:22][NH:39][CH:36]([CH3:38])[CH3:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 86604788HCID 86604788, compound

Product 1

HCID 11696440HCID 11696440, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
37.5 °C

Procedure

A mixture of 3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl-4-methylbenzenesulfonate of Formula IVa (40 g), isopropylamine (20 ml), and acetonitrile (200 ml) was stirred at 35-40° C. for 12 hours. The reaction mass was distilled completely, and the obtained residue was crystallized from ethyl acetate (280 ml) to give 28 g of the title compound as a white crystalline powder. Melting point: 137-139° C.

Workup

  1. distillationThe reaction mass was distilled completely
  2. customthe obtained residue was crystallized from ethyl acetate (280 ml)

Sources & evidence

ORD record
ord-d6eee2aed6dc4415a46364f84a9fa25f
Source dataset
uspto-grants-2008_04
Patent number
US07355077B2

Reaction notes

Loading…