反应详情

温度

66 °C

N-benzyl-N-hexyl-3-(4-hydroxyphenyl)propanamide (183 mg, 0.54 mmol), methyl 2-(bromomethyl)benzoate (136 mg, 0.59 mmol) and potassium carbonate (112 mg, 0.81 mmol) were mixed in acetonitrile. The mixture was stirred at 66° C. overnight. The solvent was evaporated under reduced pressure and the residue was dissolved in ethyl acetate. The organic phase was washed (water ×2, brine ×1), dried (Na2SO4) and evaporated. Further purification by preparative HPLC (using a gradient of CH3CN/10% CH3CN-waterphase containing 0.1M NH4OAc as eluant) gave 91 mg (yield 34%) of the desired product.

1. customThe solvent was evaporated under reduced pressure
2. dissolutionthe residue was dissolved in ethyl acetate
3. washThe organic phase was washed (water ×2, brine ×1)
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customFurther purification by preparative HPLC (
7. additioncontaining 0.1M NH4OAc as eluant)