反应详情

温度

20 °C

Potassium thiocyanate (1.08 g) is added to a solution of methyl 4-chlorocarbonylbenzoate (2 g) in acetonitrile (30 ml). After stirring for 1 hour at approximately 20° C., the mixture is filtered and the filtrate is concentrated under reduced pressure at 40° C. The solid obtained is purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate 1:1) in order to produce the expected compound (2.1 g; 95% yield).

1. filtrationthe mixture is filtered
2. concentrationthe filtrate is concentrated under reduced pressure at 40° C
3. customThe solid obtained
4. customis purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate 1:1) in order