HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenyl trifluoromethyl sulphone → (r)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenyl trifluoromethyl sulphone | HCID 136315 | — |
| Reactant | (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid | HCID 688637 | — |
| Reactant | 3-Methyl-4-pyridinecarboxaldehyde | HCID 1501880 | — |
| Product | (r)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | HCID 10075980 | — |
Reaction Steps
The compound is prepared from 0.04 mmol of resin, 0.12 mmol of N-Fmoc-D-Ala(OH), 0.20 mmol of 3-methyl-4-pyridinecarboxaldehyde and 0.10 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 6.3 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07354933B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-28cd84068e234504ab5d2055d770e042 |
| Source note | uspto-grants-2008_04 |