HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 2-Chloro-4-(chloromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 2-Chloro-4-methylpyridine | HCID 77248 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloro-4-(chloromethyl)pyridine | HCID 11126573 | — |
Reaction Steps
10 g of 2-chloro-4-methylpyridine are dissolved in 30 ml of CH3CN and a mixture of AIBN (3 g) and NCS (30 g) is added. The resulting mixture is refluxed for 4 hours. After removing the solvent, the crude product is further purified by distillation (boiling point: 70° C., 20 mtorr).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07354933B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-a825dba2cf224593bec34cd43bbf5f21 |
| Source note | uspto-grants-2008_04 |