反应详情

温度

80 °C

A mixture of 1.9 g of selenium oxide dissolved in 35 ml of dioxane is added dropwise to a solution of 2.7 g of 4-methyl-7-methoxyquinoline in 35 ml of dioxane preheated to 65° C. At the end of the addition, the brown suspension is heated to a temperature in the region of 80° C. for 5 hours. The reaction medium is stirred for 16 hours at a temperature in the region of 20° C. The greenish suspension is suction-filtered and then washed with EtOAc. The filtrate is concentrated under reduced pressure. The suspension obtained is crystallized from isopropyl ether to give 1.54 g of 7-methoxyquinoline-4-carbaldehyde.

1. custompreheated to 65° C
2. additionAt the end of the addition
3. filtrationThe greenish suspension is suction-filtered
4. washwashed with EtOAc
5. concentrationThe filtrate is concentrated under reduced pressure
6. customThe suspension obtained
7. customis crystallized from isopropyl ether