Ethanol → HCID 53434474, compound

HRID 899987Notes

Reaction equation

HRID 899987 reaction equation
S(=O)(=O)(O)O.[CH2:6]([C:8]1[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[CH:10][N:9]=1)[CH3:7].[CH2:17](O)[CH3:18]>O>[CH2:6]([C:8]1[CH:13]=[C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:11]=[CH:10][N:9]=1)[CH3:7]

Participants

5

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 101250752-Ethylisonicotinic acid

Product 1

HCID 53434474HCID 53434474, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.35 ml of concentrated sulfuric acid are added to a solution of 5 g of 2-ethylpyridine-4-carboxylic acid in 75 ml of ethanol. The reaction mixture is refluxed with stirring for about 64 hours and then concentrated to dryness under reduced pressure. The residue thus obtained is taken up in 500 ml of water and then extracted with 500 ml of dichloromethane. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure. 5.08 g of ethyl 2-ethylpyridine-4-carboxylate are thus obtained in the form of an oil.

Workup

  1. temperatureThe reaction mixture is refluxed
  2. concentrationconcentrated to dryness under reduced pressure
  3. customThe residue thus obtained
  4. extractionextracted with 500 ml of dichloromethane
  5. dry with materialThe organic phase is dried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-53538d0503634942b42b8f4677e4a83d
Source dataset
uspto-grants-2008_04
Patent number
US07354933B2

Reaction notes

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