HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → HCID 28830263, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | (3S)-(+)-1-Benzyl-3-aminopyrrolidine | HCID 1519353 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 28830263 | HCID 28830263 | 102.4% |
Reaction Steps
A mixture of (S)-1-(phenylmethyl)-3-pyrrolidinamine, (0.115 mol) and 2-propenenitrile (0.115 mol) in ethanol (250 ml) was stirred and refluxed for 2 hours. 2-Propenenitrile (1 g) was added and the reaction mixture was stirred and refluxed for another 2 hours. The solvent was evaporated, yielding 27.0 g of (S)-3-[[1-(phenyl-methyl)-3-pyrrolidinyl]amino]propanenitrile (interm. 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358239B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-14be50d74344427fa682452512c39c0c |
| Source note | uspto-grants-2008_04 |