HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 10125778, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-(Bromomethyl)-4-(trifluoromethoxy)benzene | HCID 142785 | — |
| Reactant | HCID 178527204 | HCID 178527204 | — |
| Product | HCID 10125778 | HCID 10125778 | — |
Reaction Steps
After stirring a mixture of 30 mmol of 6-mercaptopurine monohydrate (5.12 g) and 30 mmol of water-free K2CO3 (4.12 g) in 25 mL of dry DMF for 5 minutes, 30 mmol of 4-trifluormethoxybenzylbromide (6.48 g) was added. After stirring for 4 h, 200 mL of H2O was added. The obtained solid was filtered and washed with EtOAc and CH2Cl2, followed by drying under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358235B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-68a3a5f3e7a34dd7a42c8d7303f875dd |
| Source note | uspto-grants-2008_04 |