Formic Acid → 3-Chloro-4-(1-methylpiperidin-4-yloxy)nitrobenzene

HRID 90016Notes

Reaction equation

HRID 90016 reaction equation
[C:1]([O:2][C:6](=[O:3])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([Cl:24])[cH:17][c:18]([N+:21](=[O:22])[O-:23])[cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:4])([CH3:5])[CH3:7].[C:27](=[O:28])([O-:29])[O-:30].[CH2:25]=[O:26].[CH:33]([OH:34])=[O:35].[K+:31].[K+:32]>>[CH3:6][N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([Cl:24])[cH:17][c:18]([N+:21](=[O:22])[O-:23])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 284Formic AcidHCID 712FormaldehydeHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 221810984-(1-t-Butoxycarbonylpiperidin-4-yloxy)-3-chloronitrobenzene

Product 1

HCID 221810883-Chloro-4-(1-methylpiperidin-4-yloxy)nitrobenzene

Sources & evidence

ORD record
ord-0b8032c31d944f53bd172b1b8fedf088
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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