Chlorotrimethylsilane → HCID 178500031, compound

HRID 900248Notes

Reaction equation

HRID 900248 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[N:3]=[CH:2]1.[CH3:11][Si](C)(C)Cl>CO>[CH3:11][O:9][C:8](=[O:10])[CH2:7][CH2:6][C:4]1[N:3]=[CH:2][NH:1][CH:5]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 178525356HCID 178525356, compound

Product 1

HCID 178500031HCID 178500031, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 3-(1H-Imidazol-4-yl)-propionic acid (700 mg) in MeOH (20 mL) was added trimethyl chlorosilane (2 mL) dropwise. The mixture was stirred for 6 h at RT and concentrated under reduced pressure. The residue was evaporated from MeOH (1×) and from toluene (1×) to give crude 3-(1H-imidazol-4-yl)-propionic acid methyl ester as its hydrochloride salt (950 mg, colorless solid), which was used without further purification in the next step.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was evaporated from MeOH (1×) and from toluene (1×)

Sources & evidence

ORD record
ord-bcdd7f1f025949e9b0ca718e46ba64c5
Source dataset
uspto-grants-2008_04
Patent number
US07358268B2

Reaction notes

Loading…