Cesium carbonate → HCID 10460570, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-3H-imidazole-4-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide (55 mg), 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole (46 mg), Cs2CO3 (98 mg), tetrabutylammonium iodide (8 mg) and DMF (3 mL) was stirred at 80° C. for 3 h. The solvent was removed in vacuo and the residue was taken up in DCM, washed with water, and the organic layer was dried over anhydrous MgSO4 and concentrated. The title compound (6 mg) was isolated after HPLC purification of the residue as its trifluoroacetate salt. MS (ESI+): m/e=566 [M+H]+, chloro pattern.

Provenance & Evidence