Trifluoroacetic acid → HCID 69111953, compound

Participants

Reaction Conditions

Reaction Steps

To the resulting solution containing 3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-([1,4]oxazepane-4-carbonyl)-3H-imidazole-4-carboxylic acid tert-butyl ester was added TFA (216 μL). The mixture was stirred for 3 h at RT and for 3 h at 40° C. More TFA (1 mL) was added and stirring was continued at 50° C. for 2 h. The mixture was concentrated under reduced pressure. The residue was evaporated three times from toluene to provide crude 3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-([1,4]oxazepane-4-carbonyl)-3H-imidazole-4-carboxylic acid (311 mg) which was directly used in the next step.

Provenance & Evidence