Phthalic Anhydride → [4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide

Participants

Reaction Conditions

Reaction Steps

A 22 mg portion (0.070) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 15 mg (0.10 mmol) of phthalic anhydride in 140 μL of DMF. After 18 h of heating at 110° C., the mixture was cooled and purified by RP-HPLC, to give 20 mg (55%) of the desired compound. ES-MS (M+H)+=447 (Cl).

Provenance & Evidence