n-(4-Amino-3-methylphenyl) {[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide → HCID 21027614, compound

HRID 900281Notes

Reaction equation

HRID 900281 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][S:12]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)(=[O:14])=[O:13])=[O:10])=[CH:4][C:3]=1[CH3:21].[C:22]1([CH2:28]C(O)=O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F>>[Cl:20][C:17]1[S:16][C:15]([S:12]([NH:11][C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([NH:1][CH2:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[C:3]([CH3:21])[CH:4]=2)=[O:10])(=[O:14])=[O:13])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 22064409n-(4-Amino-3-methylphenyl) {[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamideHCID 131724996HCID 131724996, compound

Product 1

HCID 21027614HCID 21027614, compound

Procedure

1.0 equivalent of N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide was treated with 1.0 equivalent of PhCH2COOH/PyBOP to give X═CH2, {[(5-chloro(2-thienyl))sulfonyl]amino}-N-{3-methyl-4-[benzylamino]phenyl}carboxamide. ES-MS (M+H)+=464, 466 (Cl).

Sources & evidence

ORD record
ord-5b17f4406c7840caa11cd92bd3f2d568
Source dataset
uspto-grants-2008_04
Patent number
US07358257B2

Reaction notes

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