HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-3-methoxyphenyl)methanol → 4-Chloro-3-methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-3-methoxyphenyl)methanol | HCID 10910038 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Chloro-3-methoxybenzaldehyde | HCID 12909725 | 89.7% |
Reaction Steps
To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300 mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358257B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-b874c473b66f4db9af89ade19eb1f6b4 |
| Source note | uspto-grants-2008_04 |