反应详情

温度

180 °C

A mixture of 2-amino-6-methylbenzoic acid (5 g, 33 mmol) and formamide (15 ml) was heated in a microwave oven reactor at 180° C. for 30 min. After cooling to room temperature, the solid was collected by filtration, washed with water and dried under vacuum to give 1A (3.89 g, 73%) as a solid. The compound has an analytical HPLC retention time=1.019 min (Chromolith SpeedROD column 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA over 4 minutes, 4 mL/min, monitoring at 254 nm) and a LC/MS M++H=161+.

1. temperatureAfter cooling to room temperature
2. filtrationthe solid was collected by filtration
3. washwashed with water
4. customdried under vacuum