HCID 11676128, compound → HCID 58711714, compound

HRID 900322Notes

Reaction equation

HRID 900322 reaction equation
C(OC([C@@H:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[C:16]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]#[CH:32])[CH:26]=2)=[N:17][CH:18]=[N:19]3)[CH2:9][C@@H:8]1[C:33]([O:35][CH3:36])=[O:34])=O)C=C.[NH2:37][C@@H]1CCN(CC2C=CC=C3C=2C(NC2C=CC=C(OC)C=2)=NC=N3)C[C@H]1C(NC)=O>CO>[NH2:37][C@@H:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[C:16]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]#[CH:32])[CH:26]=2)=[N:17][CH:18]=[N:19]3)[CH2:9][C@H:8]1[C:33]([O:35][CH3:36])=[O:34]

Participants

4

Reactant 2

HCID 11676128HCID 11676128, compoundHCID 86607966HCID 86607966, compound

Product 1

HCID 58711714HCID 58711714, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 18B was prepared from 18A in a similar way as 15F. It has an analytical HPLC retention time=1.546 min (Chromolith SpeedROD column 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA over 4 minutes, 4 mL/min, monitoring at 254 nm) and a LC/MS M++H=416+.

Sources & evidence

ORD record
ord-228b19f245c64996a0cbaf400c024e56
Source dataset
uspto-grants-2008_04
Patent number
US07358256B2

Reaction notes

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