HCID 58711723, compound → HCID 11848135, compound

HRID 900327Notes

Reaction equation

HRID 900327 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:34]=[CH:35][CH:36]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[CH2:24][N:25]3[CH2:30][CH2:29][C@@H:28]([NH2:31])[C@H:27](O)[CH2:26]3)[N:17]=[CH:16][N:15]=2)=[CH:9][C:8]=1[Cl:33]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:34]=[CH:35][CH:36]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[CH2:24][N:25]3[CH2:26][CH2:27][CH:28]([NH2:31])[CH2:29][CH2:30]3)[N:17]=[CH:16][N:15]=2)=[CH:9][C:8]=1[Cl:33]

Participants

3

Reactant 1

HCID 58711723HCID 58711723, compound

Product 1

HCID 11848135HCID 11848135, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation was carried out from 20A (68 mg) in a similar way as described in example 21B in 81% yield. It has an analytical HPLC retention time=2.40 min (Chromolith SpeedROD column 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA over 4 minutes, 4 mL/min, monitoring at 254 nm) and a LC/MS M++H=492+.

Sources & evidence

ORD record
ord-058f7aa194fc4e14875b0057f69f0b03
Source dataset
uspto-grants-2008_04
Patent number
US07358256B2

Reaction notes

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