HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Iodophenyl)ethan-1-one → HCID 11390977, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Iodophenyl)ethan-1-one | HCID 72869 | — |
| Reactant | HCID 11616807 | HCID 11616807 | — |
| Product | HCID 11390977 | HCID 11390977 | — |
Reaction Steps
Starting from 4-iodophenyl methyl ketone, which is reduced to the racemic alcohol and converted to (±)-1-(4-iodophenyl)ethyl chloroacetate, the racemic ester is subjected to stereoselective enzyme hydrolysis. The remaining (S)-isomer of the ester is separated from the (R)-alcohol and transesterified to give (S)-1-(4-iodophenyl)ethanol (ee >98%) III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358369B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-fd8068368e3c41cd830ccacfce572f41 |
| Source note | uspto-grants-2008_04 |