Trimethylsilyl isocyanate → 3-(carbamoylamino)-5-thiophen-3-ylthiophene-2-carboxamide

HRID 900420Notes

Reaction equation

[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:11]=[CH:10][S:9][CH:8]=2)[S:4][C:3]=1[C:12]([NH2:14])=[O:13].C[Si]([N:19]=[C:20]=[O:21])(C)C>>[NH2:19][C:20]([NH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:11]=[CH:10][S:9][CH:8]=2)[S:4][C:3]=1[C:12]([NH2:14])=[O:13])=[O:21]

Participants

Reactant 2

HCID 70696Trimethylsilyl isocyanate

HCID 28078693-Amino-5-(3-thienyl)thiophene-2-carboxamide

Product 1

HCID 98139853-(carbamoylamino)-5-thiophen-3-ylthiophene-2-carboxamide

Procedure

Prepared by the method of Example 1 from 3-amino-5-(3-thienyl)-2-thiophenecarboxamide and trimethylsilylisocyanate.

Sources & evidence

ORD record: ord-de9a40e7484a4cba87b3b470d71e4df6
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07358376B2

Reaction notes

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