1-(2-Chloroethyl)piperidine → 3-[(Aminocarbonyl)amino]-5-{3-[2-(1-piperidinyl)ethoxy]phenyl}-2-thiophenecarboxamide

HRID 900430Notes

Reaction equation

HRID 900430 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3].Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3]

Participants

3

Procedure

Prepared by the method of Example 9(b) using the product of Example 6 and N-(2-chloroethyl)piperidine.

Workup

  1. customPrepared by the method of Example 9(b)

Sources & evidence

ORD record
ord-65183ec491ea4d69831e41f56e39990f
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Reaction notes

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