反应详情

2-Acetylamino-3-cyano-5-(4-cyanophenyl)thiophene (470 mg) was heated at reflux in ethanol (15 ml) and concentrated sulphuric acid (1.5 ml) for 2.5 h. The reaction mixture was cooled and concentrated under reduced pressure. The residue was basified with 2N sodium hydroxide, with cooling, and the product was filtered off and dried (360 mg).

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated under reduced pressure
3. temperaturewith cooling
4. filtrationthe product was filtered off
5. customdried (360 mg)