Water → 5-Bromo-2-ureidothiophene-3-carboxamide

HRID 900452Notes

Reaction equation

HRID 900452 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3].[Br:13]Br.O>C(O)(=O)C>[NH2:1][C:2]([NH:4][C:5]1[S:6][C:7]([Br:13])=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 111714022-(Carbamoylamino)thiophene-3-carboxamide

Product 1

HCID 111846265-Bromo-2-ureidothiophene-3-carboxamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

2-[(Aminocarbonyl)amino]-3-thiophenecarboxamide (1.0 g) was dissolved in acetic acid (20 ml) and a solution of bromine (0.35 ml) in acetic acid (5 ml) was added over 5 minutes with rapid stirring. The mixture was stirred for 90 minutes and then added to water (50 ml). The product was filtered off and washed with water and dried under vacuum (0.55 g).

Workup

  1. filtrationThe product was filtered off
  2. washwashed with water
  3. customdried under vacuum (0.55 g)

Sources & evidence

ORD record
ord-c46d19d0fbb44041a38abcd56a7e7ccf
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Reaction notes

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