Triacetoxyperiodinane → 2-[(4-Oxidanylidenecyclohexyl)amino]-4-(3,6,6-Trimethyl-4-Oxidanylidene-5,7-Dihydroindol-1-Yl)benzamide

Participants

Reaction Steps

The title compound of Example 3 [2-(4-Hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindol-1-yl)-benzamide] (150 mg, 0.366 mmol) and Dess-Martin periodinane (0.366 mmol) were dissolved in anhydrous CH2Cl2 and stirred at room temperature for one hour. The reaction mixture was concentrated and the title compound was isolated as a white solid (36.2 mg, 24% yield) after purification by column chromatography eluting with EtOAc-MeOH. LCMS m/z: (M+H)=408.3.

Provenance & Evidence