Hydrochloric Acid → HCID 11203656, compound

Participants

Reaction Steps

2 N Hydrochloric acid (1 mL) was added to a stirred solution of 5-benzyl-5-(2-[4′-(2-benzylbenzofuran-3-yl)-biphen-4-yl]-2-oxoethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione (200 mg) in THF (5 mL), and the resultant solution was heated at 70° C. for 6 h and then cooled to room temperature and concentrated in vacuo. The resulting solid was redissolved in DMSO (5 mL), and heated to 150° C. for 3 h before being cooled to room temperature, and diluted with water (20 mL), and extracted with ethyl acetate (3×20 mL). The combined extract was washed with water (2×10 mL), sat'd aq NaCl (3×10 mL), dried over anhyd MgSO4, filtered and concentrated in vacuo. Purification by trituration and filtration from MeOH afforded the title compound as a pale yellow solid (65 mg).

Provenance & Evidence