HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900498Generated: October 30, 2026
Water → 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile
https://huagongshe.com/reaction/900498
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 23567930 | HCID 23567930 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile | HCID 23567931 | — |
Reaction Steps
4.8 g (16 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)-acetoxy-pentane-nitrile is dissolved in 50 ml of ethanol and mixed with 1.28 g of NaOH (32 mmol). It is stirred for 3 hours at 25° C., added to 200 ml of water, extracted with 2×200 ml of MTB ether, dried on sodium sulfate and concentrated by evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07358382B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-25d91916068d4c19a320341a0eda47de |
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| Source note | uspto-grants-2008_04 |
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