反应详情

25 g (0.09 mol) of 2-trifluoromethoxy-4-(phenyldiazenyl)phenol from Example 7 and 1 g of Pd/C (10%) were initially charged in 350 ml of ethanol. The solution was degassed and aerated with hydrogen. The mixture was stirred at room temperature under a 1 bar hydrogen atmosphere for 72 hours. On completion of hydrogen uptake, the catalyst was filtered off and the filtrate concentrated on a rotary evaporator, in the course of which the product already crystallizes out. The resulting solid was filtered off with suction, washed with a little cold ethanol and dried under high vacuum for 4 hours. 8.5 g (50%) of the desired compound were obtained as a light brown powder.

1. customThe solution was degassed
2. filtrationOn completion of hydrogen uptake, the catalyst was filtered off
3. concentrationthe filtrate concentrated on a rotary evaporator, in the course of which the product
4. customalready crystallizes out
5. filtrationThe resulting solid was filtered off with suction
6. washwashed with a little cold ethanol
7. customdried under high vacuum for 4 hours