HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Ethoxy-5-oxo-tetrahydrofuran-3-yl)-carbamic acid allyl ester → HCID 22977791, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Ethoxy-5-oxo-tetrahydrofuran-3-yl)-carbamic acid allyl ester | HCID 22149038 | — |
| Reactant | {2-[2-(2-Benzyloxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-carbamic acid tert-butyl ester | HCID 22977790 | — |
| Product | HCID 22977791 | HCID 22977791 | 73% |
Reaction Steps
Prepared from (2-ethoxy-5-oxo-tetrahydro-furan-3-yl) carbamic acid allyl ester 74 following the method used in the synthesis of 75 to give the title compound as a pale yellow solid (660 mg, 73% yield). 1H-NMR (500 MHz, CD3OD) δ 1.14-1.36 (m, 6H), 1.42 (s, 9H), 1.75-2.29 (m, 4H), 2.48 (dd, 0.5H), 2.58 (dd, 0.5H), 2.72-2.85 (m, 0.5H), 2.99 (dd, 0.5H), 3.43-3.91 (m, 4H), 4.07-4.52 (m, 2.5H), 4.53-4.72 (m, 0.5H), 5.37 (s, 0.5H), 5.57 (d, 0.5H). Analytical HPLC (mixture of 2 diastereomers) 7.92, 8.14 min. LC-MS (ES+) m/e=414.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358273B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-22f168a8419740c18ee61eb4ab404960 |
| Source note | uspto-grants-2008_04 |