HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 11beta-Chloro-17beta-hydroxy-7alpha-methyl-estr-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 7alpha-Ethyl-11beta-fluoro-17beta-hydroxy-estr-4-en-3-one | HCID 9901642 | — |
| Reactant | 7alpha-Ethyl-11beta-fluoro-estr-4-en-3,17-dione | HCID 69104987 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Product | 11beta-Chloro-17beta-hydroxy-7alpha-methyl-estr-4-en-3-one | HCID 9858365 | — |
Reaction Steps
In analogy to Example 1 7α-Ethyl-11β-fluoro-17β-hydroxy-estr-4-en-3-one, using ethylmagnesium bromide instead of methylmagnesium bromide, is obtained; Fp. 115.1° C., [α]D20=+62,1° (in chloroform). The intermediate 7α-Ethyl-11β-fluoro-estr-4-en-3,17-dione shows Fp.=174.9° C. and [α]D20=+107,1° (chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361645B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-5890cdf7e50c49cbbae6d71b65d9c14b |
| Source note | uspto-grants-2008_04 |