HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900685Generated: October 25, 2026
Piperazine → Methyl 3-fluoro-4-(piperazin-1-yl)benzoate
https://huagongshe.com/reaction/900685
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Methyl 3,4-difluorobenzoate | HCID 2775358 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 3-fluoro-4-(piperazin-1-yl)benzoate | HCID 18425273 | — |
Reaction Steps
Anhydrous piperazine was added to a THF solution of methyl 3,4-difluorobenzoate, and the mixture was stirred at 60° C. for 18 hours to obtain methyl 3-fluoro-4-piperazin-1-ylbenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07361658B2 |
|---|
| Source dataset | uspto-grants-2008_04 |
|---|
| ORD ID | ord-14289cc71cd6418a91293c16a9d87490 |
|---|
| Source note | uspto-grants-2008_04 |
|---|
