Diethyl Ether → 4-(4-Chlorothiophen-2-yl)-1,3-thiazol-2-amine

Participants

Reaction Steps

Bromine was added to an ether solution of 4-chloro-2-acetylthiophene under ice cooling, and the mixture was stirred at room temperature for 2 hours to obtain a brominated compound. Thiourea was added to an EtOH solution of the brominated compound at room temperature, and the mixture was stirred overnight at 80° C. to obtain 2-amino-4-(4-chlorothiophen-2-yl)thiazole.

Provenance & Evidence