Ethyl 4-piperidinecarboxylate → HCID 23117199, compound

Participants

Reaction Steps

1.3 ml of ethyl isonipecotate was added to a 5 ml THF solution of 413 mg of 5,6-dichloro-N-[4-(4-chlorothiophen-2-yl)-5-(piperidin-1-ylmethyl)-1,3-thiazol-2-yl]nicotinamide, and the mixture was stirred for 5 days. After the solvent was distilled off under reduced pressure, a saturated sodium hydrogencarbonate aqueous solution was added, and the resulting precipitate was collected by filtration. The precipitate was dissolved in chloroform, and a saturated sodium hydrogencarbonate aqueous solution was added. The mixture was extracted with chloroform, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography using hexane:EtOAc (4:1 to 3:1) as an elution solvent to obtain 468 mg of ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(piperidinomethyl)thiazol-2-yl]carbamoyl}-2-pyridyl)piperidine-4-carboxylate.

Provenance & Evidence