Acetic Acid → Nicotinic Acid

Participants

Reaction Conditions

Reaction Steps

Isonicotinic acid hydrazide (1.06 g, 7.73 mmol) and trimethylsilyl isothiocyanate (2.03 g, 15.4 mmol) were dissolved in acetic acid (2.0 ml) in a round bottom flask with a condenser and stirred magnetically at 105° C. overnight. The solution was cooled to room temperature, at which time a solid formed. The acetic acid solution was decanted and any remaining solvent was evaporated with heating on a rotary evaporator. This residue was carried on as such to the next step.

Provenance & Evidence