Isoniazid → HCID 10634519, compound

Participants

Reaction Steps

Isonicotinohydrazide (10.96 g, 79.9 mmol) was dissolved in ethanol (80 ml) containing potassium hydroxide (5.3 g, 94.4 mmol). Carbon disulfide was then added with stirring, which was continued for 1 hr. Filtration gave crude potassium 3-isonicotinoyldithiocarbazate which was washed with ether and then dried in vacuum. This was then added slowly with stirring to concentrated sulfuric acid (25 ml) maintained at −5° C. Stirring was continued for an additional 5 min and then the reaction mixture was poured into crushed ice. After 10 min, the solid was filtered off to give 5-(pyridine-4′yl)-1,3,4-thiadiazole-2(3H)-thione.

Provenance & Evidence