1-Hydroxybenzotriazole → HCID 10141615, compound

Participants

Reaction Steps

1-Hydroxybenzotriazole (0.14 g) was added to a solution of the product of step b) (0.25 g) in dichloromethane (5 ml). After stirring for 5 minutes, 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride (0.21 g) was added. After stirring for 10 minutes, N,O-dimethylhydroxylamine hydrochloride (0.1 g) and triethylamine (0.15 ml) were added The reaction mixture was stirred for 12 h at room temperature. The solution was concentrated in vacuo. The residue was purified by flash silica chromatography eluting with a gradient of 0-3% methanol in dichloromethane to give the title compound as a yellow solid (0.118 g).

Provenance & Evidence