Hydrochloric Acid → HCID 69292865, compound

Participants

Reaction Conditions

Reaction Steps

The N-methoxy-N-methyl amide was dissolved in dry THF (10 ml) and cooled down to 0° C. A 3M etheral phenyl magnesium bromide solution (17.5 ml, 52.5 mmol) was added dropwise and then the mixture was heated at 65° C. for 1 hour. The mixture was cooled at room temperature and carefully treated with a 1 N HCl solution for 30 minutes at 40° C. The solution was diluted with ether and the organic phase separated, dried over MgSO4 and concentrated. The residual oil was chromatographied on silica gel (CH2Cl2/hexane 10/90) and the 4-cyclohepten-1-yl(phenyl)methanone 21 was isolated as a colorless oil (1.35 g, 77%).

Provenance & Evidence