HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexyl phenyl ketone → 1-cyclohexyl-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenylprop-2-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexyl phenyl ketone | HCID 12837 | — |
| Reactant | (3R)-3-ethynyl-1-azabicyclo[2.2.2]oct-3-yl methyl ether | HCID 9812856 | — |
| Product | 1-cyclohexyl-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenylprop-2-yn-1-ol | HCID 44406573 | — |
Reaction Steps
1-cyclohexyl-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]oct-3-yl]-1-phenyl-2-propyn-1-ol 201 was prepared as described in 4.1 (method 1) using cyclohexyl(phenyl)methanone and (3R)-3-ethynyl-1-azabicyclo[2.2.2]oct-3-yl methyl ether 53.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361668B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-f9077de3a11e40d19977dfe7b907c126 |
| Source note | uspto-grants-2008_04 |