1,2-Dimethoxyethane → HCID 23086891, compound

Participants

Reaction Steps

To 25 ml of 1,2-dimethoxyethane were added about 2.0 g of 5-chloro-3-methylthio-1,2,4-thiadiazole, 2.25 g of 2-chlorophenylboronic acid, 694 mg of tetrakistriphenylphosphine palladium and 25 ml of a 2 M aqueous sodium carbonate solution, and the mixture was heated under reflux for 3 hours in a nitrogen atmosphere. Then, the reaction mixture was poured into water, and the mixture was extracted with t-butyl methyl ether. The organic layer was dried over anhydrous sodium sulfate, and the residue obtained by concentration was subjected to silica gel column chromatography to obtain 1.67 g of 3-methylthio-5-(3-chlorophenyl)-1,2,4-thiadiazole.

Provenance & Evidence