HCID 86607102, compound → HCID 86607103, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 2-acetamido-4-methyl-thiazole-5-sulfonic acid (2-hydroxy-ethyl)-amide (0.95 g, 3.4 mmol) in 6N hydrochloric acid (13 ml) was heated for 2 h at 80° C., evaporated, and saturated NaHCO3 solution (20 ml) was added. The mixture was extracted with ethyl acetate (3×50 ml), the combined organic layers washed with brine (50 ml) and dried (MgSO4). The crude product was further purified by crystallization (dichloromethane/MeOH/hexane) to yield the title compound (0.51 g, 63%) as a white solid. MS (ISP) 236.0 [(M−H)−]; mp 151° C.

Provenance & Evidence