Triethylamine → HCID 86607109, compound

Participants

Reaction Steps

To a stirred solution of 1-methylpiperazine (1.18 g, 11.8 mmol) in THF (24 ml) was added at 0° C. (ice water bath) commercially available 2-acetamido-4-methylthiazole-5-sulfonyl chloride (2.0 g, 7.85 mmol) and triethylamine (1.2 ml, 8.6 mmol). The light yellow suspension was stirred at room temperature for 17 h, and evaporated. The crude product was further purified by column chromatography on silica gel (dichloromethane/MeOH 9:1) and subsequent crystallization (dichloromethane/MeOH/hexane) to yield 2-acetamido-4-methyl-thiazole-5-sulfonic acid (4-methylpiperazinyl)-amide (1.85 g, 74%) as a white solid. MS (ISP) 319.0 [(M+H)+]; mp 245° C.

Provenance & Evidence