HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1,3,4-thiadiazole-2-sulfonamide → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1,3,4-thiadiazole-2-sulfonamide | HCID 84724 | — |
| Reactant | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 66650268 | — |
| Product | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | HCID 11995694 | — |
Reaction Steps
The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 5-amino-[1,3,4]thiadiazole-2-sulfonic acid amide [commercially available, CAS 14949-00-9] according to general procedure II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361659B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-004aacf72bfb40c99c7a652cd2dd38f3 |
| Source note | uspto-grants-2008_04 |